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What is the effect of Biotin (vitamin B7) on improvements in fatigue for males diagnosed with progressive MS?

A previous Biotin study on MS ended up producing no statistically significant difference in symptoms compared to placebo. A closer look at the individuals who participated in the Biotin study showed some benefit in terms of a reduction in fatigue by using 100mg of Biotin (vitamin B7) three times daily. Those individuals diagnosed with MS who benefited from Biotin were male and had progressive MS. An updated study on Biotin needs to be conduced using the same dosage amount where the only participants taking part in the updated study are male and have been diagnosed with progressive MS (no RRMS patients).
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